A mouse model for ulcerative colitis based on NOD-scid IL2R Î³null mice reconstituted with peripheral blood mononuclear cells from affected individuals.

Palamides, Pia; Jodeleit, Henrika; Föhlinger, Michael; Beigel, Florian; Herbach, Nadja; Mueller, Thomas; Wolf, Eckhard; Siebeck, Matthias; Gropp, Roswitha

Palamides, Pia; Jodeleit, Henrika; Föhlinger, Michael; Beigel, Florian; Herbach, Nadja; Mueller, Thomas; Wolf, Eckhard; Siebeck, Matthias; Gropp, Roswitha.

Afiliação

Palamides P; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich 81377, Germany Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich 81377, Germany.
Jodeleit H; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich 81377, Germany Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich 81377, Germany.
Föhlinger M; Department of General- Visceral-, and Transplantation Surgery, Hospital of the University of Munich, Nussbaumstr. 20, Munich 80336, Germany.
Beigel F; Department of Medicine II-Grosshadern, Ludwig Maximilians University, Munich, Germany.
Herbach N; Institute of Veterinary Pathology, Ludwig Maximilians University, Munich, Germany.
Mueller T; Julius von Sachs Institute, University of Würzburg, Würzburg 97082, Germany.
Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich 81377, Germany Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich 81377, Germany.
Siebeck M; Department of General- Visceral-, and Transplantation Surgery, Hospital of the University of Munich, Nussbaumstr. 20, Munich 80336, Germany.
Gropp R; Department of General- Visceral-, and Transplantation Surgery, Hospital of the University of Munich, Nussbaumstr. 20, Munich 80336, Germany Roswitha.gropp@med.uni-muenchen.de.

Dis Model Mech ; 9(9): 985-97, 2016 09 01.

Article em En | MEDLINE | ID: mdl-27491073

Assuntos

Colite Ulcerativa/sangue; Colite Ulcerativa/patologia; Subunidade gama Comum de Receptores de Interleucina/deficiência; Leucócitos Mononucleares/metabolismo; Animais; Forma Celular/efeitos dos fármacos; Colite Ulcerativa/tratamento farmacológico; Colite Ulcerativa/metabolismo; Colo/patologia; Modelos Animais de Doenças; Etanol; Fator de Crescimento de Hepatócito/metabolismo; Humanos; Inflamação/patologia; Infliximab/farmacologia; Infliximab/uso terapêutico; Subunidade gama Comum de Receptores de Interleucina/metabolismo; Interleucina-4/farmacologia; Interleucina-4/uso terapêutico; Leucócitos Mononucleares/efeitos dos fármacos; Leucócitos Mononucleares/imunologia; Receptores de Lipopolissacarídeos/metabolismo; Camundongos Endogâmicos NOD; Camundongos SCID; Monócitos/efeitos dos fármacos; Monócitos/metabolismo; Baço/patologia; Linfócitos T/efeitos dos fármacos; Linfócitos T/metabolismo; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

Infliximab; NSG mice; Pitrakinra; Ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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