N-terminal Prion Protein Peptides (PrP(120-144)) Form Parallel In-register ß-Sheets via Multiple Nucleation-dependent Pathways.

Wang, Yiming; Shao, Qing; Hall, Carol K

Wang, Yiming; Shao, Qing; Hall, Carol K.

Afiliação

Wang Y; From the Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, 27695-7905.
Shao Q; From the Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, 27695-7905.
Hall CK; From the Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, 27695-7905 hall@ncsu.edu.

J Biol Chem ; 291(42): 22093-22105, 2016 Oct 14.

Article em En | MEDLINE | ID: mdl-27576687

Assuntos

Amiloide/química; Proteínas PrPC/química; Agregados Proteicos; Animais; Arvicolinae; Cricetinae; Humanos; Mesocricetus; Estrutura Secundária de Proteína

Palavras-chave

amino acid substitution; amyloid core; discontinuous molecular dynamics; fibril; kinetics; prion disease; protein aggregation; thermodynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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