Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.

Hao, Jielu; Wei, Qingqing; Mei, Shuqin; Li, Lin; Su, Yunchao; Mei, Changlin; Dong, Zheng

Hao, Jielu; Wei, Qingqing; Mei, Shuqin; Li, Lin; Su, Yunchao; Mei, Changlin; Dong, Zheng.

Afiliação

Hao J; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Wei Q; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Mei S; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Li L; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Su Y; Department of Pharmacology and Toxicology, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Mei C; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: chlmei1954@126.com.
Dong Z; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA; Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: zdong@augusta.edu.

Kidney Int ; 91(1): 106-118, 2017 01.

Article em En | MEDLINE | ID: mdl-27622990

Assuntos

Injúria Renal Aguda/metabolismo; MicroRNAs/metabolismo; Receptores do Fator de Necrose Tumoral/metabolismo; Traumatismo por Reperfusão/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Injúria Renal Aguda/etiologia; Animais; Apoptose; Benzotiazóis/farmacologia; Caspases/metabolismo; Linhagem Celular; Modelos Animais de Doenças; Hipóxia/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Túbulos Renais/citologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mutação; Traumatismo por Reperfusão/complicações; Transdução de Sinais; Tolueno/análogos & derivados; Tolueno/farmacologia; Proteína Supressora de Tumor p53/antagonistas & inibidores; Proteína Supressora de Tumor p53/genética; Regulação para Cima

Palavras-chave

acute kidney injury; death receptor; ischemia-reperfusion injury; microRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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