The toll-like receptor 4 antagonist transforming growth factor-ß-activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells.

Pan, Long-Fei; Yu, Lei; Wang, Li-Ming; He, Jun-Tao; Sun, Jiang-Li; Wang, Xiao-Bo; Bai, Zheng-Hai; Su, Li-Juan; Pei, Hong-Hong

Pan, Long-Fei; Yu, Lei; Wang, Li-Ming; He, Jun-Tao; Sun, Jiang-Li; Wang, Xiao-Bo; Bai, Zheng-Hai; Su, Li-Juan; Pei, Hong-Hong.

Afiliação

Pan LF; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yu L; Department of Clinical Laboratory, Xi'an Medical College, Xi'an, Shaanxi, China.
Wang LM; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
He JT; Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Sun JL; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang XB; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Bai ZH; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Su LJ; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Pei HH; Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: peihonghong_xjtu@126.com.

J Surg Res ; 206(2): 298-306, 2016 12.

Article em En | MEDLINE | ID: mdl-27884323

Assuntos

Células Acinares/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Pancreatite/tratamento farmacológico; Substâncias Protetoras/uso terapêutico; Sulfonamidas/uso terapêutico; Receptor 4 Toll-Like/antagonistas & inibidores; Células Acinares/metabolismo; Animais; Apoptose/efeitos dos fármacos; Biomarcadores/metabolismo; Western Blotting; Sobrevivência Celular/efeitos dos fármacos; Marcação In Situ das Extremidades Cortadas; Peroxidação de Lipídeos/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias/metabolismo; Pancreatite/induzido quimicamente; Pancreatite/metabolismo; Substâncias Protetoras/farmacologia; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Sulfonamidas/farmacologia; Ácido Taurocólico

Palavras-chave

Acute pancreatitis; Mitochondrial dysfunction; Oxidative stress; TLR4

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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