Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair.

Ronchi, Giulia; Cillino, Michele; Gambarotta, Giovanna; Fornasari, Benedetta Elena; Raimondo, Stefania; Pugliese, Pierfrancesco; Tos, Pierluigi; Cordova, Adriana; Moschella, Francesco; Geuna, Stefano

Ronchi, Giulia; Cillino, Michele; Gambarotta, Giovanna; Fornasari, Benedetta Elena; Raimondo, Stefania; Pugliese, Pierfrancesco; Tos, Pierluigi; Cordova, Adriana; Moschella, Francesco; Geuna, Stefano.

Afiliação

Ronchi G; Department of Clinical and Biological Sciences.
Cillino M; Neuroscience Institute Cavalieri Ottolenghi, and.
Gambarotta G; Plastic and Reconstructive Surgery, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.
Fornasari BE; Department of Clinical and Biological Sciences.
Raimondo S; Department of Clinical and Biological Sciences.
Pugliese P; Department of Clinical and Biological Sciences.
Tos P; Neuroscience Institute Cavalieri Ottolenghi, and.
Cordova A; Reconstructive Microsurgery, Centro Traumatologico Ortopedico Hospital, University of Torino; and.
Moschella F; Reconstructive Microsurgery, Centro Traumatologico Ortopedico Hospital, University of Torino; and.
Geuna S; Plastic and Reconstructive Surgery, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

J Neurosurg ; 127(4): 843-856, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28059646

Assuntos

Regeneração Nervosa; Traumatismos dos Nervos Periféricos/fisiopatologia; Células de Schwann; Animais; Denervação; Feminino; Degeneração Neural; Neuregulina-1/fisiologia; Ratos; Ratos Wistar; Recuperação de Função Fisiológica; Fatores de Tempo

Palavras-chave

ANKRD27 = ankyrin repeat domain 27; GAPDH = glyceraldehyde-3-phosphate-dehydrogenase; GFAP = glial fibrillary acidic protein; MBP = myelin basic protein; NRG1 = neuregulin 1; NRG1/ErbB system; NTF = N-terminal fragment; PCR = polymerase chain reaction; RICTOR = RPTOR independent companion of MTOR complex 2; RT = reverse transcription; delayed nerve repair; nerve degeneration; nerve regeneration; neuregulin 1; p75 = low-affinity nerve growth factor receptor; peripheral nerve; stereology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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