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Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
Elwood, Fiona; Witter, David J; Piesvaux, Jennifer; Kraybill, Brian; Bays, Nathan; Alpert, Carla; Goldenblatt, Peter; Qu, Yujie; Ivanovska, Irena; Lee, Hyun-Hee; Chiu, Chi-Sung; Tang, Hao; Scott, Mark E; Deshmukh, Sujal V; Zielstorff, Mark; Byford, Alan; Chakravarthy, Kalyan; Dorosh, Lauren; Rivkin, Alexey; Klappenbach, Joel; Pan, Bo-Sheng; Kariv, Ilona; Dinsmore, Christopher; Slipetz, Deborah; Dandliker, Peter J.
Afiliação
  • Elwood F; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Witter DJ; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Piesvaux J; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Kraybill B; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Bays N; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Alpert C; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Goldenblatt P; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Qu Y; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Ivanovska I; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Lee HH; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Chiu CS; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Tang H; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Scott ME; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Deshmukh SV; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Zielstorff M; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Byford A; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Chakravarthy K; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Dorosh L; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Rivkin A; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Klappenbach J; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Pan BS; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Kariv I; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Dinsmore C; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Slipetz D; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
  • Dandliker PJ; Departments of Respiratory and Immunology (F.E., Y.Q., I.I., H.-H.L., H.T., D.S.), Chemistry (D.W., M.E.S., A.R., C.D.), Pharmacology (J.P., B.K., N.B., C.A., P.G., M.Z., A.B., K.C., B.-S.P., I.K., P.J.D.), and Pharmacokinetics, Pharmacodynamics and Drug Metabolism (C.-S.C., S.V.D., L.D., J.K.), Mer
J Pharmacol Exp Ther ; 361(2): 229-244, 2017 05.
Article em En | MEDLINE | ID: mdl-28193636
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article