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Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity.
Boulenouar, Selma; Michelet, Xavier; Duquette, Danielle; Alvarez, David; Hogan, Andrew E; Dold, Christina; O'Connor, Donal; Stutte, Suzanne; Tavakkoli, Ali; Winters, Desmond; Exley, Mark A; O'Shea, Donal; Brenner, Michael B; von Andrian, Ulrich; Lynch, Lydia.
Afiliação
  • Boulenouar S; Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Michelet X; Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Duquette D; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Alvarez D; Harvard Medical School, Boston, MA 02115, USA.
  • Hogan AE; Education Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland.
  • Dold C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • O'Connor D; Education Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland.
  • Stutte S; Harvard Medical School, Boston, MA 02115, USA.
  • Tavakkoli A; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Winters D; Education Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland.
  • Exley MA; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • O'Shea D; Education Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland.
  • Brenner MB; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • von Andrian U; Harvard Medical School, Boston, MA 02115, USA.
  • Lynch L; Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: llynch@bwh.harvard.edu.
Immunity ; 46(2): 273-286, 2017 02 21.
Article em En | MEDLINE | ID: mdl-28228283
Adipose tissue has a dynamic immune system that adapts to changes in diet and maintains homeostatic tissue remodeling. Adipose type 1 innate lymphoid cells (AT1-ILCs) promote pro-inflammatory macrophages in obesity, but little is known about their functions at steady state. Here we found that human and murine adipose tissue harbor heterogeneous populations of AT1-ILCs. Experiments using parabiotic mice fed a high-fat diet (HFD) showed differential trafficking of AT1-ILCs, particularly in response to short- and long-term HFD and diet restriction. At steady state, AT1-ILCs displayed cytotoxic activity toward adipose tissue macrophages (ATMs). Depletion of AT1-ILCs and perforin deficiency resulted in alterations in the ratio of inflammatory to anti-inflammatory ATMs, and adoptive transfer of AT1-ILCs exacerbated metabolic disorder. Diet-induced obesity impaired AT1-ILC killing ability. Our findings reveal a role for AT1-ILCs in regulating ATM homeostasis through cytotoxicity and suggest that this function is relevant in both homeostasis and metabolic disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article