Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Thomas, Jeffrey D; Longen, Charles G; Oyer, Halley M; Chen, Nan; Maher, Christina M; Salvino, Joseph M; Kania, Blase; Anderson, Kelsey N; Ostrander, William F; Knudsen, Karen E; Kim, Felix J

Thomas, Jeffrey D; Longen, Charles G; Oyer, Halley M; Chen, Nan; Maher, Christina M; Salvino, Joseph M; Kania, Blase; Anderson, Kelsey N; Ostrander, William F; Knudsen, Karen E; Kim, Felix J.

Afiliação

Thomas JD; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Longen CG; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Oyer HM; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Chen N; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Maher CM; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Salvino JM; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Kania B; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Anderson KN; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Ostrander WF; Department of Cancer Biology, Sidney Kimmel College of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania.
Knudsen KE; Department of Cancer Biology, Sidney Kimmel College of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania.
Kim FJ; Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania.

Cancer Res ; 77(9): 2439-2452, 2017 05 01.

Article em En | MEDLINE | ID: mdl-28235766

Assuntos

Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Isoformas de Proteínas/genética; Receptores Androgênicos/genética; Receptores sigma/genética; 17-Cetosteroides/metabolismo; Antagonistas de Androgênios/administração & dosagem; Androgênios/metabolismo; Androstanóis/metabolismo; Animais; Linhagem Celular Tumoral; Humanos; Masculino; Camundongos; Neoplasias de Próstata Resistentes à Castração/genética; Neoplasias de Próstata Resistentes à Castração/patologia; Receptores sigma/antagonistas & inibidores; Ensaios Antitumorais Modelo de Xenoenxerto; Receptor Sigma-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article