Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice.

Dai, Bingyang; Li, Qiangqiang; Song, Xiaoxiao; Ge, Yuxiang; Wu, Jing; Zhang, Kaijia; Wang, Chao; Zhang, Yifeng; Teng, Huajian; Li, Chaojun; Jiang, Qing

Dai, Bingyang; Li, Qiangqiang; Song, Xiaoxiao; Ge, Yuxiang; Wu, Jing; Zhang, Kaijia; Wang, Chao; Zhang, Yifeng; Teng, Huajian; Li, Chaojun; Jiang, Qing.

Afiliação

Dai B; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Li Q; Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Song X; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Ge Y; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Wu J; Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Zhang K; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Wang C; Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Zhang Y; The School of Medicine, Nanjing University, Nanjing, 210093, People's Republic of China.
Teng H; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Li C; Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Jiang Q; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.

J Bone Miner Metab ; 36(2): 133-147, 2018 Mar.

Article em En | MEDLINE | ID: mdl-28357594

Assuntos

Condrócitos/metabolismo; Farnesiltranstransferase/metabolismo; Consolidação da Fratura; Técnicas de Silenciamento de Genes; Complexos Multienzimáticos/metabolismo; Osteogênese; Animais; Biomarcadores/metabolismo; Fenômenos Biomecânicos; Proteína Morfogenética Óssea 2/metabolismo; Calo Ósseo/metabolismo; Calo Ósseo/patologia; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Farnesiltranstransferase/deficiência; Fêmur/irrigação sanguínea; Fêmur/diagnóstico por imagem; Fêmur/patologia; Fêmur/fisiopatologia; Consolidação da Fratura/genética; Regulação da Expressão Gênica; Antígeno Ki-67/metabolismo; Masculino; Camundongos Knockout; Complexos Multienzimáticos/deficiência; Neovascularização Fisiológica; Osteogênese/genética; Transdução de Sinais; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

Bone fracture; Endochondral ossification; Geranylgeranyl diphosphate synthase 1; Intramembranous ossification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article