Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans.

Masuo, Yusuke; Nagamori, Shushi; Hasegawa, Aoi; Hayashi, Kazuki; Isozumi, Noriyoshi; Nakamichi, Noritaka; Kanai, Yoshikatsu; Kato, Yukio

Masuo, Yusuke; Nagamori, Shushi; Hasegawa, Aoi; Hayashi, Kazuki; Isozumi, Noriyoshi; Nakamichi, Noritaka; Kanai, Yoshikatsu; Kato, Yukio.

Afiliação

Masuo Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences,, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Nagamori S; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hasegawa A; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences,, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Hayashi K; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences,, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Isozumi N; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nakamichi N; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences,, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Kanai Y; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kato Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences,, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan. ykato@p.kanazawa-u.ac.jp.

Pharm Res ; 34(6): 1233-1243, 2017 06.

Article em En | MEDLINE | ID: mdl-28361200

Assuntos

Microssomos Hepáticos/metabolismo; Monoaminoxidase/metabolismo; Fenilefrina/metabolismo; Sumatriptana/metabolismo; Triazóis/metabolismo; Triptaminas/metabolismo; Humanos; Cinética; Taxa de Depuração Metabólica; Fenilefrina/farmacologia; Sumatriptana/farmacologia; Triazóis/farmacologia; Triptaminas/farmacologia

Palavras-chave

Drug metabolism; Hepatic clearance; In vitro-in vivo extrapolation; Monoamine oxidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article