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Squaramide-Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions.
Sakai, Takaaki; Hirashima, Shin-Ichi; Yamashita, Yoshifumi; Arai, Ryoga; Nakashima, Kosuke; Yoshida, Akihiro; Koseki, Yuji; Miura, Tsuyoshi.
Afiliação
  • Sakai T; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Hirashima SI; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Yamashita Y; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Arai R; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Nakashima K; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Yoshida A; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Koseki Y; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • Miura T; Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
J Org Chem ; 82(9): 4661-4667, 2017 05 05.
Article em En | MEDLINE | ID: mdl-28394134
ABSTRACT
Asymmetric direct vinylogous aldol reactions of furan-2(5H)-one with aldehydes in the presence of a catalytic amount of novel squaramide-sulfonamide organocatalyst resulted in the corresponding addition products with high to excellent enantioselectivities. This is the first successful report illustrating an example of highly stereoselective reactions using a squaramide-sulfonamide organocatalyst.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article