Major Developments in the Design of Inhibitors along the Kynurenine Pathway.

Jacobs, Kelly R; Castellano-Gonzalez, Gloria; Guillemin, Gilles J; Lovejoy, David B

Jacobs, Kelly R; Castellano-Gonzalez, Gloria; Guillemin, Gilles J; Lovejoy, David B.

Afiliação

Jacobs KR; Neuroinflammation Group, Department of Biomedical Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney. Australia.
Castellano-Gonzalez G; Neuroinflammation Group, Department of Biomedical Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney. Australia.
Guillemin GJ; Department of Biomedical Research, Faculty of Medicine and Health Science, Macquarie University, 2 Technology Place, Sydney. Australia.
Lovejoy DB; Department of Biomedical Research, Faculty of Medicine and Health Science, Macquarie University, 2 Technology Place, Sydney. Australia.

Curr Med Chem ; 24(23): 2471-2495, 2017.

Article em En | MEDLINE | ID: mdl-28464785

Assuntos

Desenho de Fármacos; Inibidores Enzimáticos/farmacologia; Indolamina-Pirrol 2,3,-Dioxigenase/antagonistas & inibidores; Quinurenina 3-Mono-Oxigenase/antagonistas & inibidores; Cinurenina/metabolismo; Transaminases/antagonistas & inibidores; Inibidores Enzimáticos/química; Inibidores Enzimáticos/metabolismo; Humanos; Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo; Quinurenina 3-Mono-Oxigenase/metabolismo; Transaminases/metabolismo

Palavras-chave

3-dioxygenase; Kynurenine pathway; cancer; enzyme inhibitors; indoleamine 2; kynurenine 3- monooxygenase; neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article