Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells.

Kim, Kwang-Youn; Park, Kwang-Il; Kim, Sang-Hun; Yu, Sun-Nyoung; Park, Sul-Gi; Kim, Young Woo; Seo, Young-Kyo; Ma, Jin-Yeul; Ahn, Soon-Cheol

Kim, Kwang-Youn; Park, Kwang-Il; Kim, Sang-Hun; Yu, Sun-Nyoung; Park, Sul-Gi; Kim, Young Woo; Seo, Young-Kyo; Ma, Jin-Yeul; Ahn, Soon-Cheol.

Afiliação

Kim KY; Department of Herbal Formula, Medical Research Center (MRC-GHF), College of Oriental Medicine, Daegu Haany University, Gyeongsan 38610, Korea. lokyve@dhu.ac.kr.
Park KI; Department of Microbiology & Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea. lokyve@dhu.ac.kr.
Kim SH; Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Korea. kipark@kiom.re.kr.
Yu SN; Department of Microbiology & Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea. kshphone@nate.com.
Park SG; Department of Microbiology & Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea. gurisn@naver.com.
Kim YW; Department of Microbiology & Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea. betoje0728@gmail.com.
Seo YK; Department of Herbal Formula, Medical Research Center (MRC-GHF), College of Oriental Medicine, Daegu Haany University, Gyeongsan 38610, Korea. ywkim@dhu.ac.kr.
Ma JY; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea. ykseo@unist.ac.kr.
Ahn SC; Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Korea. jyma@kiom.re.kr.

Int J Mol Sci ; 18(5)2017 May 18.

Article em En | MEDLINE | ID: mdl-28524116

Assuntos

Autofagia/efeitos dos fármacos; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Piranos/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores; Flavonoides/farmacologia; Humanos; Imidazóis/farmacologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Inibidores de Fosfoinositídeo-3 Quinase; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-akt/metabolismo; Piridinas/farmacologia; Serina-Treonina Quinases TOR/antagonistas & inibidores; Proteínas Quinases p38 Ativadas por Mitógeno/antagonistas & inibidores

Palavras-chave

apoptosis; autophagy; prostate cancer cells; reactive oxygen species; salinomycin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article