Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1ß-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition.

Meng, Qingliang; Du, Xuzhao; Wang, Huilian; Gu, Huimin; Zhan, Junping; Zhou, Zipeng

Meng, Qingliang; Du, Xuzhao; Wang, Huilian; Gu, Huimin; Zhan, Junping; Zhou, Zipeng.

Afiliação

Meng Q; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China.
Du X; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China.
Wang H; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China.
Gu H; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China.
Zhan J; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China. jpzhanmola@163.com.
Zhou Z; Department of Rheumatism Branch, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Jinshui District, Zhengzhou City, 450002, Henan Province, People's Republic of China.

Apoptosis ; 22(9): 1138-1146, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28660311

Assuntos

Astragalus propinquus/química; Autofagia/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Polissacarídeos/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Sinoviócitos/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Apoptose/efeitos dos fármacos; Artrite Reumatoide/metabolismo; Artrite Reumatoide/fisiopatologia; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Citocinas/metabolismo; Interleucina-1beta/farmacologia; Ratos; Transdução de Sinais/efeitos dos fármacos; Sinoviócitos/citologia; Sinoviócitos/patologia

Palavras-chave

Apoptosis; Astragalus polysaccharides; Autophagy; Pro-inflammatory cytokines; Rheumatoid arthritis fibroblast-like synoviocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article