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ß cell function and insulin resistance in lean cases with polycystic ovary syndrome.
Pande, Arunkumar R; Guleria, Ashwani Kumar; Singh, Sudhanshu Dev; Shukla, Manoj; Dabadghao, Preeti.
Afiliação
  • Pande AR; a Endocrinology , Sahara Hospital , Lucknow , India.
  • Guleria AK; b Endocrinology , Endocrine Diabetes and Thyroid Clinic , Lucknow , India.
  • Singh SD; c Department of Endocrinology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , India.
  • Shukla M; d Amar Hospital , Patiala , India.
  • Dabadghao P; e Zulekha Hospital , Dubai , UAE.
Gynecol Endocrinol ; 33(11): 877-881, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28704124
ABSTRACT
Obesity is a major factor in development of insulin resistance (IR) and metabolic features in polycystic ovary syndrome (PCOS) patients. Nearly two-thirds patients with PCOS (30 of 37 confirmed cases of PCOS) in our previous community based study were lean, in contrast to Caucasians. Metabolic parameters including IR and ß cell function have not been characterized well in this group of lean PCOS. To study the metabolic features including IR and ß cell function in lean PCOS patients, 53 patients with BMI, <23 kg/m2 were compared with 71 obese PCOS and 45 age and body mass index matched controls. Lean patients had similar ß cell function and IR as compared to controls and obese patients, though the latter group had more metabolic abnormality. Fasting c-peptide and its ratio to glucose were significantly higher in lean patients compared to controls. In subset of subjects with five point OGTT, disposition index and Matsuda index (MI) showed significant negative correlation with BMI and blood pressure. MI also negatively correlated with waist, WHR, and HOMAB. High fasting C-peptide is probably a class effect as is seen in both lean and obese PCOS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article