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5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.
Beaufils, Florent; Cmiljanovic, Natasa; Cmiljanovic, Vladimir; Bohnacker, Thomas; Melone, Anna; Marone, Romina; Jackson, Eileen; Zhang, Xuxiao; Sele, Alexander; Borsari, Chiara; Mestan, Jürgen; Hebeisen, Paul; Hillmann, Petra; Giese, Bernd; Zvelebil, Marketa; Fabbro, Doriano; Williams, Roger L; Rageot, Denise; Wymann, Matthias P.
Afiliação
  • Beaufils F; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Cmiljanovic N; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Cmiljanovic V; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Bohnacker T; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Melone A; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Marone R; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Jackson E; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Zhang X; MRC Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, U.K.
  • Sele A; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Borsari C; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Mestan J; PIQUR Therapeutics AG , Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  • Hebeisen P; PIQUR Therapeutics AG , Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  • Hillmann P; PIQUR Therapeutics AG , Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  • Giese B; Department of Chemistry, University of Basel , St. Johanns-Ring 19, 4056 Basel, Switzerland.
  • Zvelebil M; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Fabbro D; PIQUR Therapeutics AG , Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  • Williams RL; MRC Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, U.K.
  • Rageot D; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
  • Wymann MP; Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.
J Med Chem ; 60(17): 7524-7538, 2017 09 14.
Article em En | MEDLINE | ID: mdl-28829592
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article