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Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity.
Sheng, Jiansong; Tran, Phu N; Li, Zhihua; Dutta, Sara; Chang, Kelly; Colatsky, Thomas; Wu, Wendy W.
Afiliação
  • Sheng J; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.
  • Tran PN; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.
  • Li Z; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.
  • Dutta S; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.
  • Chang K; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States.
  • Colatsky T; Seabrook Island, SC 29455, United States.
  • Wu WW; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, the US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. Electronic address: Wendy.Wu@fda.hhs.gov.
J Pharmacol Toxicol Methods ; 88(Pt 2): 109-122, 2017.
Article em En | MEDLINE | ID: mdl-28830713
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article