Anti-fatigue activity of a Lachnum polysaccharide and its carboxymethylated derivative in mice.
Bioorg Med Chem Lett
; 27(20): 4777-4780, 2017 10 15.
Article
em En
| MEDLINE
| ID: mdl-28911818
ABSTRACT
The present study was designed to evaluate the anti-fatigue activity of an exopolysaccharide LEP-1b and its carboxymethylated derivative CLEP-1b from a Lachnum sp. Carboxymethylation was confirmed through FT-IR and 13C NMR spectroscopies, which showed that the (-CH2COOH) group was attached to an oxygen (O) atom of the hydroxyl group on (C-3) of LEP-1b. Each treatment group LEP-1b and CLEP-1b at doses (50, 100, 200mg/kg, respectively) ameliorated physical fatigue and extended exhaustive swimming time in mice. Results of the fatigue related biochemical markers showed that LEP-1b and CLEP-1b at doses (50, 100, 200mg/kg, respectively) increased the content of hepatic glycogen and decreased the level of serum urea nitrogen and lactic acid. Additionally, LEP-1b and CLEP-1b enhanced the antioxidant enzymes' activities and reduced the lipid peroxidation. Moreover, results revealed that CLEP-1b had higher anti-fatigue activity than LEP-1b at same doses but without statistical significance, especially CLEP-1b (200mg/kg) had strong anti-fatigue effects. Therefore, LEP-1b and CLEP-1b can potentially be exploited as a kind of healthcare compound to combat fatigue and to boost physical strength.
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01-internacional
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MEDLINE
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Animals
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En
Ano de publicação:
2017
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Article