Risk factors associated with the carotid intima-media thickness and plaques: ESPREDIA Study. / Factores de riesgo asociados con el grosor íntima-media y la presencia de placas en arteria carótida: Estudio ESPREDIA.
Clin Investig Arterioscler
; 30(2): 49-55, 2018.
Article
em En, Es
| MEDLINE
| ID: mdl-28939054
ABSTRACT
OBJECTIVE:
To evaluate whether there were any differences in the risk factor profile associated with either the intima-media thickness (IMT) or the presence of carotid plaques.METHODS:
Cross-sectional study in 1475 subjects between 45 and 75years, randomly selected from the population of the Northwest area of Madrid (Spain). They had a physical exam, blood analysis, and ultrasound measurement of the IMT and of the presence of plaques.RESULTS:
Mean IMT was 0.725±0.132mm. Forty seven percent of the participants had carotid plaques. In multivariate analysis, factors directly associated with the IMT were, age (ß0.227, P<.0001), sex (ß0.104, P<.0001), presence of hypertension (ß0.082, P=.002), diabetes (ß0.130, P<.0001) and current smoking (ß0.107, P<.0001), systolic blood pressure (SBP) (ß0.219, P<.0001) and LDL-cholesterol levels (ß0.074, P=.003), and inversely, diastolic blood pressure (DBP) (ß-0.124, P=.001), HDL-cholesterol (ß-0.111, P<.0001) and triglyceride levels (ß-0.060, P=.028). The presence of plaques was directly associated with age (OR1.08; 95%CI 1.05-1.10), sex (OR1.95; 95%CI 1.52-2.51), current smoking (OR2.75; 95%CI 1.92-3.95), history of hypertension (OR1.58; 95%CI 1.22-2.04) or diabetes (OR1.84; 95%CI 1.31-2.58), statin treatment (OR1.56; 95%CI 1.19-2.04) and SBP (OR1.03; 95%CI 1.02-1.05), and inversely with DBP (OR0.98; 95%CI 0.96-0.99).CONCLUSION:
Factors associated with the IMT and the presence of plaques are similar, a finding that support a continuum between muscular layer hypertrophy and arteriosclerosis development.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
/
Es
Ano de publicação:
2018
Tipo de documento:
Article