Pharmacodynamics, pharmacokinetics and safety of revefenacin (TD-4208), a long-acting muscarinic antagonist, in patients with chronic obstructive pulmonary disease (COPD): Results of two randomized, double-blind, phase 2 studies.

Quinn, Dean; Barnes, Christopher N; Yates, Wayne; Bourdet, David L; Moran, Edmund J; Potgieter, Peter; Nicholls, Andrew; Haumann, Brett; Singh, Dave

Quinn, Dean; Barnes, Christopher N; Yates, Wayne; Bourdet, David L; Moran, Edmund J; Potgieter, Peter; Nicholls, Andrew; Haumann, Brett; Singh, Dave.

Afiliação

Quinn D; P3 Research, 121 Adelaide Road, Mount Cook, Wellington, New Zealand. Electronic address: dean@p3research.co.nz.
Barnes CN; Theravance Biopharma US, Inc., South San Francisco, CA, United States. Electronic address: cbarnes@theravance.com.
Yates W; Theravance Biopharma US, Inc., South San Francisco, CA, United States. Electronic address: wyates@theravance.com.
Bourdet DL; Theravance Biopharma US, Inc., South San Francisco, CA, United States. Electronic address: dbourdet@theravance.com.
Moran EJ; Theravance Biopharma US, Inc., South San Francisco, CA, United States. Electronic address: emoran@theravance.com.
Potgieter P; Theravance Biopharma UK, Limited, London, United Kingdom. Electronic address: peterpotgieter2@aol.com.
Nicholls A; Pharmaceutical Consulting, Burlingame, CA, United States. Electronic address: andrew.10.nicholls@gmail.com.
Haumann B; Theravance Biopharma UK, Limited, London, United Kingdom. Electronic address: bhaumann@theravance.com.
Singh D; University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester, NHS Foundation Trust, Manchester, United Kingdom. Electronic address: dsingh@meu.org.uk.

Pulm Pharmacol Ther ; 48: 71-79, 2018 02.

Article em En | MEDLINE | ID: mdl-28987804

Assuntos

Benzamidas/administração & dosagem; Broncodilatadores/administração & dosagem; Carbamatos/administração & dosagem; Antagonistas Muscarínicos/administração & dosagem; Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico; Administração por Inalação; Idoso; Benzamidas/efeitos adversos; Benzamidas/farmacocinética; Broncodilatadores/efeitos adversos; Broncodilatadores/farmacocinética; Carbamatos/efeitos adversos; Carbamatos/farmacocinética; Estudos Cross-Over; Método Duplo-Cego; Feminino; Volume Expiratório Forçado; Humanos; Ipratrópio/uso terapêutico; Masculino; Pessoa de Meia-Idade; Antagonistas Muscarínicos/efeitos adversos; Antagonistas Muscarínicos/farmacocinética; Nebulizadores e Vaporizadores; Espirometria; Fatores de Tempo

Palavras-chave

Anti-muscarinic; Bronchodilator; COPD; Inhalation; Long-acting muscarinic antagonist; Nebulized; Once-daily; Rapid onset; Revefenacin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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