Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities.

Ge, Bing-Chen; Feng, Hong-Fang; Cheng, Yu-Fang; Wang, Hai-Tao; Xi, Bao-Ming; Yang, Xue-Mei; Xu, Jiang-Ping; Zhou, Zhong-Zhen

Ge, Bing-Chen; Feng, Hong-Fang; Cheng, Yu-Fang; Wang, Hai-Tao; Xi, Bao-Ming; Yang, Xue-Mei; Xu, Jiang-Ping; Zhou, Zhong-Zhen.

Afiliação

Ge BC; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Feng HF; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Cheng YF; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Wang HT; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Xi BM; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Yang XM; Hygiene Detection Center, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Xu JP; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: jpx@smu.edu.cn.
Zhou ZZ; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: zhouzz@smu.edu.cn.

Eur J Med Chem ; 141: 440-445, 2017 Dec 01.

Article em En | MEDLINE | ID: mdl-29040954

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Desenho de Fármacos; Piridinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Fase G1/efeitos dos fármacos; Humanos; Estrutura Molecular; Piridinas/síntese química; Piridinas/química; Fase de Repouso do Ciclo Celular/efeitos dos fármacos; Relação Estrutura-Atividade

Palavras-chave

Antiproliferative activities; Apoptosis; Cell cycle arrest; Pyridazin-3(2H)-one derivatives; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article