Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy.

Schlüter, A; Horstmann, M; Diaz-Cano, S; Plöhn, S; Stähr, K; Mattheis, S; Oeverhaus, M; Lang, S; Flögel, U; Berchner-Pfannschmidt, U; Eckstein, A; Banga, J P

Schlüter, A; Horstmann, M; Diaz-Cano, S; Plöhn, S; Stähr, K; Mattheis, S; Oeverhaus, M; Lang, S; Flögel, U; Berchner-Pfannschmidt, U; Eckstein, A; Banga, J P.

Afiliação

Schlüter A; Molecular Ophthalmology, Departments of Ophthalmology University Hospital Essen, Germany.
Horstmann M; Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, Essen, Germany.
Diaz-Cano S; Molecular Ophthalmology, Departments of Ophthalmology University Hospital Essen, Germany.
Plöhn S; Department of Histopathology, King's College Hospital NHS, London, UK.
Stähr K; Molecular Ophthalmology, Departments of Ophthalmology University Hospital Essen, Germany.
Mattheis S; Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, Essen, Germany.
Oeverhaus M; Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, Essen, Germany.
Lang S; Department of Ophthalmology, University Hospital Essen, Essen, Germany.
Flögel U; Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, Essen, Germany.
Berchner-Pfannschmidt U; Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Eckstein A; Molecular Ophthalmology, Departments of Ophthalmology University Hospital Essen, Germany.
Banga JP; Molecular Ophthalmology, Departments of Ophthalmology University Hospital Essen, Germany.

Clin Exp Immunol ; 191(3): 255-267, 2018 03.

Article em En | MEDLINE | ID: mdl-29058307

Assuntos

Autoantígenos/imunologia; Doença de Graves/imunologia; Oftalmopatia de Graves/imunologia; Inflamação/imunologia; Nervo Óptico/imunologia; Receptores da Tireotropina/imunologia; Tireoidite Autoimune/imunologia; Animais; Autoanticorpos/genética; Modelos Animais de Doenças; Suscetibilidade a Doenças; Feminino; Humanos; Imunização; Camundongos; Camundongos Endogâmicos; Camundongos Knockout; Miosite Orbital; Plasmídeos/imunologia; Receptores da Tireotropina/genética; Tolerância a Antígenos Próprios

Palavras-chave

Graves' disease; Graves' orbitopathy; autoimmunity; self-antigen mouse model; thyroid disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article