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[Effect of B Cell Differentiation Markers on the Prognosis of Primary Central Nervous System Lymphoma].
Chen, Xiang-Lei; Li, Xiao-Yun; Wang, Wei.
Afiliação
  • Chen XL; Department of Radio Therapy, Yidu Central Hospital of Weifang, Weifang 262500, Shangdong Province, China.
  • Li XY; Department of Neurology, Yidu Central Hospital of Weifang, Weifang 262500, Shangdong Province, China.
  • Wang W; Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. E-mail:wwdwt@163.com.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 25(5): 1410-1414, 2017 Oct.
Article em Zh | MEDLINE | ID: mdl-29070116
ABSTRACT

OBJECTIVE:

To investigate the value of B-cell differentiation markers in prognosis evaluation of 119 patients with primary CNS lymphoma(PCNSL).

METHODS:

The expressions of BCL-2, BCL-6, CD10 and MUM1/IRF4 protein were determined by immunohistochemistry, and their relationship with the prognosis of primary central nervous system lymphoma was analyzed.

RESULTS:

Univariate analysis showed that BCL-6 positive means shorter PFS (P=0.047) and OS (P=0.035). Multivariate analysis showed that BCL-6 positive expression was related with shorter PFS (hazard ratio1.95, 95% CI 1.22- 3.12, P=0.005), but did not relate with OS (hazard ratio 1.85, 95% CI 0.71- 4.80, P=0.21). Classification based on Hans algorithm and expression status of the single B-cell markers BCL-2, CD10 and MUM1/IRF4 did not correlate with prognosis.

CONCLUSION:

BCL-6 may be an unfavorable prognostic biomarker for PCNSL.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article