Activation of bombesin receptor Subtype-3 by [D-Tyr6,ß-Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes.

Moreno-Villegas, Zaida; Martín-Duce, Antonio; Aparicio, César; Portal-Núñez, Sergio; Sanz, Raúl; Mantey, Samuel A; Jensen, Robert T; Lorenzo, Oscar; Egido, Jesús; González, Nieves

Activation of bombesin receptor Subtype-3 by [D-Tyr⁶,ß-Ala¹¹,Phe¹³,Nle¹⁴]bombesin_6-14 increased glucose uptake and lipogenesis in human and rat adipocytes.

Moreno-Villegas, Zaida; Martín-Duce, Antonio; Aparicio, César; Portal-Núñez, Sergio; Sanz, Raúl; Mantey, Samuel A; Jensen, Robert T; Lorenzo, Oscar; Egido, Jesús; González, Nieves.

Afiliação

Moreno-Villegas Z; Renal, Vascular and Diabetes Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain.
Martín-Duce A; Department of Nursery, Unit of Surgery, Universidad de Alcalá, Madrid, Spain.
Aparicio C; Department of Vascular Surgery, Hospital Fundación Jiménez Díaz, Madrid, Spain.
Portal-Núñez S; Bone and Joint Research Unit, IIS-FJD, Madrid, Spain; Applied Molecular Medicine Institute, School of Medicine, Universidad San Pablo CEU, CEU Universities, Madrid, Spain.
Sanz R; ATG Medical, Madrid, Spain.
Mantey SA; National Institutes of Health, Cell Biology Section, NIDDK, Digestive Disease Branch, Bethesda, MD, USA.
Jensen RT; National Institutes of Health, Cell Biology Section, NIDDK, Digestive Disease Branch, Bethesda, MD, USA.
Lorenzo O; Renal, Vascular and Diabetes Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain; Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
Egido J; Renal, Vascular and Diabetes Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain; Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
González N; Renal, Vascular and Diabetes Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain; Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. Electronic address: ng

Mol Cell Endocrinol ; 474: 10-19, 2018 10 15.

Article em En | MEDLINE | ID: mdl-29402494

Assuntos

Adipócitos/metabolismo; Bombesina/farmacologia; Glucose/metabolismo; Lipogênese/efeitos dos fármacos; Receptores da Bombesina/metabolismo; Adipócitos/efeitos dos fármacos; Animais; Transporte Biológico/efeitos dos fármacos; Regulação da Expressão Gênica/efeitos dos fármacos; Transportador de Glucose Tipo 4/metabolismo; Humanos; Insulina/farmacologia; Masculino; Fosforilação/efeitos dos fármacos; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos Wistar; Receptores da Bombesina/agonistas; Receptores da Bombesina/genética

Palavras-chave

Adipose tissue; BRS-3; Diabetes; GLUT-4; Glucose metabolism; obesity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article