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The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity.
Lupien, Sonia J; Juster, Robert-Paul; Raymond, Catherine; Marin, Marie-France.
Afiliação
  • Lupien SJ; Centre for Studies on Human Stress, Montreal Mental Health University Institute, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada. Electronic address: sonia.lupien@umontreal.ca.
  • Juster RP; Centre for Studies on Human Stress, Montreal Mental Health University Institute, Canada; Department of Psychiatry, Columbia University, New York, United States.
  • Raymond C; Centre for Studies on Human Stress, Montreal Mental Health University Institute, Canada; Department of Neurosciences, Université de Montreal, Canada.
  • Marin MF; Centre for Studies on Human Stress, Montreal Mental Health University Institute, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada.
Front Neuroendocrinol ; 49: 91-105, 2018 04.
Article em En | MEDLINE | ID: mdl-29421159
ABSTRACT
For the last five decades, science has managed to delineate the mechanisms by which stress hormones can impact on the human brain. Receptors for glucocorticoids are found in the hippocampus, amygdala and frontal cortex, three brain regions involved in memory processing and emotional regulation. Studies have shown that chronic exposure to stress is associated with reduced volume of the hippocampus and that chronic stress can modulate volumes of both the amygdala and frontal cortex, suggesting neurotoxic effects of stress hormones on the brain. Yet, other studies report that exposure to early adversity and/or familial/social stressors can increase vulnerability to stress in adulthood. Models have been recently developed to describe the roles that neurotoxic and vulnerability effects can have on the developing brain. These models suggest that developing early stress interventions could potentially counteract the effects of chronic stress on the brain and results going along with this hypothesis are summarized.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article