CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9.

Dugar, Gaurav; Leenay, Ryan T; Eisenbart, Sara K; Bischler, Thorsten; Aul, Belinda U; Beisel, Chase L; Sharma, Cynthia M

Dugar, Gaurav; Leenay, Ryan T; Eisenbart, Sara K; Bischler, Thorsten; Aul, Belinda U; Beisel, Chase L; Sharma, Cynthia M.

Afiliação

Dugar G; Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany.
Leenay RT; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Eisenbart SK; Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany.
Bischler T; Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany.
Aul BU; Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany.
Beisel CL; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA; Helmholtz Institute for RNA-based Infection Research (HIRI), Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany. Electronic address: cbeisel@ncsu.edu.
Sharma CM; Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Josef-Schneider-Str. 2 / D15, D-97080 Würzburg, Germany. Electronic address: cynthia.sharma@uni-wuerzburg.de.

Mol Cell ; 69(5): 893-905.e7, 2018 03 01.

Article em En | MEDLINE | ID: mdl-29499139

Assuntos

Proteína 9 Associada à CRISPR/metabolismo; Sistemas CRISPR-Cas/fisiologia; Campylobacter jejuni/enzimologia; Estabilidade de RNA/fisiologia; RNA Bacteriano/metabolismo; RNA Mensageiro/metabolismo; Proteína 9 Associada à CRISPR/genética; Campylobacter jejuni/genética; DNA Bacteriano/genética; DNA Bacteriano/metabolismo; Domínios Proteicos; RNA Bacteriano/genética; RNA Mensageiro/genética

Palavras-chave

CRISPR; Campylobacter jejuni; Cas9; RIP-seq; RNA binding proteins; RNA cleavage; crRNA; genome editing; non-coding RNA; post-transcriptional regulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article