HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.

Cao, Chunyu; Wu, Hao; Vasilatos, Shauna N; Chandran, Uma; Qin, Ye; Wan, Yong; Oesterreich, Steffi; Davidson, Nancy E; Huang, Yi

Cao, Chunyu; Wu, Hao; Vasilatos, Shauna N; Chandran, Uma; Qin, Ye; Wan, Yong; Oesterreich, Steffi; Davidson, Nancy E; Huang, Yi.

Afiliação

Cao C; Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Wu H; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Vasilatos SN; Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Chandran U; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Qin Y; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Wan Y; Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Oesterreich S; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Davidson NE; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Huang Y; Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Int J Cancer ; 143(6): 1388-1401, 2018 09 15.

Article em En | MEDLINE | ID: mdl-29633255

Assuntos

Apoptose/efeitos dos fármacos; Biomarcadores Tumorais/metabolismo; Neoplasias da Mama/patologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Histona Desacetilases/metabolismo; Histona Desmetilases/metabolismo; Isotiocianatos/farmacologia; Animais; Biomarcadores Tumorais/genética; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Proliferação de Células/efeitos dos fármacos; Epigênese Genética; Feminino; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/química; Histona Desacetilases/genética; Histona Desmetilases/antagonistas & inibidores; Histona Desmetilases/genética; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; RNA Interferente Pequeno/genética; Sulfóxidos; Células Tumorais Cultivadas; Fatores Estimuladores Upstream/genética; Fatores Estimuladores Upstream/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

HCI-2509; HDAC5; LSD1; USF1; breast cancer; combination therapy; sulforaphane

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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