A sensitive, high-throughput, and ecofriendly method for the determination of lumefantrine, artemether, and its active metabolite dihydroartemisinin by supercritical fluid chromatography and tandem mass spectrometry.

Yang, Yinxian; Gao, Hailing; Hou, Shanshan; Su, Ruijuan; Liu, Hongzhuo; Sun, Jin

Yang, Yinxian; Gao, Hailing; Hou, Shanshan; Su, Ruijuan; Liu, Hongzhuo; Sun, Jin.

Afiliação

Yang Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Gao H; College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Hou S; College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Su R; College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Liu H; College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Sun J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China.

J Sep Sci ; 41(12): 2688-2696, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29660250

Assuntos

Artemisininas/sangue; Cromatografia com Fluido Supercrítico/métodos; Etanolaminas/sangue; Fluorenos/sangue; Espectrometria de Massas em Tandem/métodos; Animais; Artemeter; Artemisininas/metabolismo; Etanolaminas/metabolismo; Fluorenos/metabolismo; Lumefantrina; Masculino; Ratos; Ratos Sprague-Dawley; Sensibilidade e Especificidade

Palavras-chave

artemether; dihydroartemisinin; lumefantrine; mass spectrometry; supercritical fluid chromatography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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