A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.

Ferrer, Elisabet; Dunmore, Benjamin J; Hassan, Dhiya; Ormiston, Mark L; Moore, Stephen; Deighton, John; Long, Lu; Yang, Xu Dong; Stewart, Duncan J; Morrell, Nicholas W

Ferrer, Elisabet; Dunmore, Benjamin J; Hassan, Dhiya; Ormiston, Mark L; Moore, Stephen; Deighton, John; Long, Lu; Yang, Xu Dong; Stewart, Duncan J; Morrell, Nicholas W.

Afiliação

Ferrer E; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Dunmore BJ; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Hassan D; 2 Department of Cellular and Molecular Medicine, Faculty of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada; and.
Ormiston ML; 3 Department of Biomedical and Molecular Sciences.
Moore S; 4 Department of Medicine, and.
Deighton J; 5 Department of Surgery, Queen's University, Kingston, Ontario, Canada.
Long L; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Yang XD; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Stewart DJ; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Morrell NW; 1 Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Am J Respir Cell Mol Biol ; 59(4): 467-478, 2018 10.

Article em En | MEDLINE | ID: mdl-29676587

Assuntos

Biomarcadores Tumorais/metabolismo; Exossomos/metabolismo; Hipertensão Pulmonar/metabolismo; Hipertensão Pulmonar/fisiopatologia; Artéria Pulmonar/metabolismo; Artéria Pulmonar/fisiopatologia; Remodelação Vascular; Animais; Apoptose; Biomarcadores Tumorais/sangue; Receptores de Proteínas Morfogenéticas Ósseas Tipo II/genética; Movimento Celular; Proliferação de Células; Forma Celular; Modelos Animais de Doenças; Células Endoteliais/metabolismo; Exossomos/ultraestrutura; Humanos; Hipertensão Pulmonar/sangue; Hipertensão Pulmonar/patologia; Lentivirus/metabolismo; Pulmão/metabolismo; Masculino; Monocrotalina; Mutação/genética; Miócitos de Músculo Liso/metabolismo; Transporte Proteico; Artéria Pulmonar/patologia; Ratos Sprague-Dawley; Proteína Tumoral 1 Controlada por Tradução

Palavras-chave

endothelium; exosomes; hypertension; pulmonary; remodeling

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google