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Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Geuijen, Cecile A W; De Nardis, Camilla; Maussang, David; Rovers, Eric; Gallenne, Tristan; Hendriks, Linda J A; Visser, Therese; Nijhuis, Roy; Logtenberg, Ton; de Kruif, John; Gros, Piet; Throsby, Mark.
Afiliação
  • Geuijen CAW; Merus NV, 3584 Utrecht, the Netherlands.
  • De Nardis C; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 Utrecht, the Netherlands.
  • Maussang D; Merus NV, 3584 Utrecht, the Netherlands.
  • Rovers E; Merus NV, 3584 Utrecht, the Netherlands.
  • Gallenne T; Merus NV, 3584 Utrecht, the Netherlands.
  • Hendriks LJA; Merus NV, 3584 Utrecht, the Netherlands.
  • Visser T; Merus NV, 3584 Utrecht, the Netherlands.
  • Nijhuis R; Merus NV, 3584 Utrecht, the Netherlands.
  • Logtenberg T; Merus NV, 3584 Utrecht, the Netherlands.
  • de Kruif J; Merus NV, 3584 Utrecht, the Netherlands.
  • Gros P; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 Utrecht, the Netherlands.
  • Throsby M; Merus NV, 3584 Utrecht, the Netherlands. Electronic address: m.throsby@merus.nl.
Cancer Cell ; 33(5): 922-936.e10, 2018 05 14.
Article em En | MEDLINE | ID: mdl-29763625
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article