Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/Î³H2AX pathway.

Wang, Zhong; Chen, Qiang; Li, Bin; Xie, Jia-Ming; Yang, Xiao-Dong; Zhao, Kui; Wu, Yong; Ye, Zhen-Yu; Chen, Zheng-Rong; Qin, Zheng-Hong; Xing, Chun-Gen

Wang, Zhong; Chen, Qiang; Li, Bin; Xie, Jia-Ming; Yang, Xiao-Dong; Zhao, Kui; Wu, Yong; Ye, Zhen-Yu; Chen, Zheng-Rong; Qin, Zheng-Hong; Xing, Chun-Gen.

Afiliação

Wang Z; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Chen Q; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Li B; Department of General Surgery, the First People's Hospital of Wu Jiang, Suzhou, 215200, China.
Xie JM; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Yang XD; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Zhao K; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Wu Y; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Ye ZY; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Chen ZR; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China.
Qin ZH; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Science, Soochow Universi
Xing CG; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, 215007, China. xingcgchn@163.com.

Acta Pharmacol Sin ; 39(10): 1645-1660, 2018 Oct.

Article em En | MEDLINE | ID: mdl-29849127

Assuntos

Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Dano ao DNA/efeitos dos fármacos; Escina/uso terapêutico; Proteína Sequestossoma-1/metabolismo; Animais; Antineoplásicos/farmacologia; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Autofagia/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Regulação para Baixo; Escina/farmacologia; Feminino; Histonas/genética; Histonas/metabolismo; Humanos; Camundongos Nus; Proteína Sequestossoma-1/genética; Transdução de Sinais/efeitos dos fármacos; Regulação para Cima

Palavras-chave

HCT116 cells; HCT8 cells; apoptosis, colorectal cancer; escin, p62, DNA damage, ATM/Î³H2AX pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article