Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma.

Cui, Chaochu; Chang, Yan; Zhang, Xiaoli; Choi, Sangyong; Tran, Henry; Penmetsa, Kumar V; Viswanadha, Srikant; Fu, Liwu; Pan, Zui

Cui, Chaochu; Chang, Yan; Zhang, Xiaoli; Choi, Sangyong; Tran, Henry; Penmetsa, Kumar V; Viswanadha, Srikant; Fu, Liwu; Pan, Zui.

Afiliação

Cui C; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA; Henan Key Laboratory of Medical Tissue Regener
Chang Y; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA.
Zhang X; Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, USA.
Choi S; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA.
Tran H; Department of Biology, University of Texas at Arlington, Arlington, TX, USA.
Penmetsa KV; Rhizen Pharmaceuticals SA, La Chaux-de-Fonds, Switzerland.
Viswanadha S; Incozen Therapeutics Private Limited, Hyderabad, India.
Fu L; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: fulw@mail.sysu.edu.cn.
Pan Z; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA. Electronic address: zui.pan@uta.edu.

Cancer Lett ; 432: 169-179, 2018 09 28.

Article em En | MEDLINE | ID: mdl-29908962

Assuntos

Antineoplásicos/farmacologia; Bloqueadores dos Canais de Cálcio/farmacologia; Canais de Cálcio/química; Cálcio/metabolismo; Carcinoma de Células Escamosas/patologia; Neoplasias Esofágicas/patologia; Proteína ORAI1/metabolismo; Compostos Orgânicos/farmacologia; Animais; Antineoplásicos/uso terapêutico; Apoptose; Sinalização do Cálcio/efeitos dos fármacos; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/metabolismo; Ciclo Celular; Movimento Celular; Proliferação de Células; Neoplasias Esofágicas/tratamento farmacológico; Neoplasias Esofágicas/metabolismo; Humanos; Masculino; Camundongos; Camundongos Nus; NF-kappa B/genética; NF-kappa B/metabolismo; Proteína ORAI1/genética; Compostos Orgânicos/uso terapêutico; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cell proliferation; Esophageal cancer; Intracellular Ca(2+) oscillations; SOCE

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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