Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.

Jiang, Haiyan; Du, Jinlin; Song, Juan; Li, Yanqi; Wu, Mengjuan; Zhou, Jing; Wu, Shengzhou

Jiang, Haiyan; Du, Jinlin; Song, Juan; Li, Yanqi; Wu, Mengjuan; Zhou, Jing; Wu, Shengzhou.

Afiliação

Jiang H; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Du J; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Song J; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Li Y; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Wu M; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Zhou J; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China.
Wu S; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, Zhejiang, 325003, PR China. Electronic address: wszlab@wmu.edu.cn.

Exp Eye Res ; 175: 90-97, 2018 10.

Article em En | MEDLINE | ID: mdl-29913163

Assuntos

Retinopatia Diabética/prevenção & controle; Modelos Animais de Doenças; Mutação com Perda de Função/genética; Racemases e Epimerases/genética; Degeneração Retiniana/prevenção & controle; Células Ganglionares da Retina/metabolismo; Animais; Glicemia/metabolismo; Contagem de Células; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Diabetes Mellitus Experimental/prevenção & controle; Retinopatia Diabética/metabolismo; Retinopatia Diabética/patologia; Técnica Indireta de Fluorescência para Anticorpo; Técnicas de Genotipagem; Hiperglicemia/metabolismo; Hiperglicemia/patologia; Marcação In Situ das Extremidades Cortadas; Insulina/genética; Camundongos; Camundongos Endogâmicos C57BL; Microscopia de Fluorescência; Reação em Cadeia da Polimerase; Degeneração Retiniana/metabolismo; Células Ganglionares da Retina/patologia

Palavras-chave

D-serine; Diabetic retinopathy; Ins2(Akita); Retinal degeneration; Retinal ganglion cell

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google