Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFß1-Smad2/3 axis.

Chen, Jianhui; Lu, Junhui; Wang, Baolan; Zhang, Xiaolei; Huang, Qiuyang; Yuan, Jun; Hao, Hairong; Chen, Xing; Zhi, Junchao; Zhao, Lan; Chu, Haiqing

Chen, Jianhui; Lu, Junhui; Wang, Baolan; Zhang, Xiaolei; Huang, Qiuyang; Yuan, Jun; Hao, Hairong; Chen, Xing; Zhi, Junchao; Zhao, Lan; Chu, Haiqing.

Afiliação

Chen J; Tongji University School of Medicine, Shanghai 200092, China; Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, China.
Lu J; Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, China.
Wang B; Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu, China.
Zhang X; Jiangsu Vocational College of Nursing, Huai'an 223003, Jiangsu, China.
Huang Q; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huai'an 223003, Jiangsu, China.
Yuan J; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huai'an 223003, Jiangsu, China.
Hao H; Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, China.
Chen X; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huai'an 223003, Jiangsu, China.
Zhi J; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huai'an 223003, Jiangsu, China.
Zhao L; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China. Electronic address: zhaolan26@126.com.
Chu H; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China. Electronic address: chu_haiqing@126.com.

Int J Biol Macromol ; 118(Pt B): 2163-2175, 2018 Oct 15.

Article em En | MEDLINE | ID: mdl-30030077

Assuntos

Dendrobium/química; Polissacarídeos/uso terapêutico; Fibrose Pulmonar/tratamento farmacológico; Transdução de Sinais; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Animais; Bleomicina; Líquido da Lavagem Broncoalveolar/citologia; Contagem de Células; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Hidroxiprolina/metabolismo; Pulmão/efeitos dos fármacos; Pulmão/patologia; Masculino; Polissacarídeos/farmacologia; Fibrose Pulmonar/sangue; Fibrose Pulmonar/genética; Fibrose Pulmonar/patologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos Sprague-Dawley; Proteínas Smad/genética; Fator de Crescimento Transformador beta1/sangue; Fator de Crescimento Transformador beta1/genética

Palavras-chave

Polysaccharides from Dendrobium officinale; Pulmonary fibrosis; TGFß1-Smad2/3 axis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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