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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.
Huang, Xianhai; Brubaker, Jason; Zhou, Wei; Biju, Purakkattle J; Xiao, Li; Shao, Ning; Huang, Ying; Dong, Li; Liu, Zhidan; Bitar, Rema; Buevich, Alexei; Jung, Joon; Peterson, Scott L; Butcher, John W; Close, Joshua; Martinez, Michelle; MacCoss, Rachel N; Zhang, Hongjun; Crawford, Scott; McCormick, Kevin D; Aslanian, Robert; Nargund, Ravi; Correll, Craig; Gervais, Francois; Qiu, Hongchen; Yang, Xiaoxin; Garlisi, Charles; Rindgen, Diane; Maloney, Kevin M; Siliphaivanh, Phieng; Palani, Anandan.
Afiliação
  • Huang X; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Brubaker J; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Zhou W; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Biju PJ; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Xiao L; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Shao N; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Huang Y; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Dong L; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Liu Z; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Bitar R; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Buevich A; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Jung J; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Peterson SL; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Butcher JW; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Close J; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Martinez M; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • MacCoss RN; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Zhang H; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Crawford S; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • McCormick KD; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Aslanian R; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Nargund R; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Correll C; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Gervais F; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Qiu H; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Yang X; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Garlisi C; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Rindgen D; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Maloney KM; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Siliphaivanh P; Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Palani A; Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
ACS Med Chem Lett ; 9(7): 679-684, 2018 Jul 12.
Article em En | MEDLINE | ID: mdl-30034600
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article