Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.

Zhang, Dong-Yang; Zhang, Chun-Feng; Fu, Bi-Cheng; Sun, Lu; Wang, Xue-Qing; Chen, Wei; Liu, Wei; Liu, Kai-Yu; Du, Guo-Qing; Ma, Chong-Yi; Jiang, Shu-Lin; Li, Ren-Ke; Tian, Hai

Zhang, Dong-Yang; Zhang, Chun-Feng; Fu, Bi-Cheng; Sun, Lu; Wang, Xue-Qing; Chen, Wei; Liu, Wei; Liu, Kai-Yu; Du, Guo-Qing; Ma, Chong-Yi; Jiang, Shu-Lin; Li, Ren-Ke; Tian, Hai.

Afiliação

Zhang DY; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhang CF; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Fu BC; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Sun L; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Wang XQ; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Chen W; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Liu W; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Liu KY; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Du GQ; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Ma CY; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Jiang SL; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li RK; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Tian H; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.

J Cell Mol Med ; 22(11): 5504-5517, 2018 11.

Article em En | MEDLINE | ID: mdl-30091830

Assuntos

Envelhecimento/genética; Infarto do Miocárdio/genética; Isquemia Miocárdica/genética; Sirtuína 3/genética; Envelhecimento/patologia; Animais; Antioxidantes; Medula Óssea/metabolismo; Catalase/genética; Terapia Baseada em Transplante de Células e Tecidos/métodos; Proteína Forkhead Box O3/genética; Regulação da Expressão Gênica no Desenvolvimento; Humanos; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais/metabolismo; Infarto do Miocárdio/patologia; Infarto do Miocárdio/terapia; Isquemia Miocárdica/patologia; Isquemia Miocárdica/terapia; Estresse Oxidativo/genética; Plasmídeos/genética; Substâncias Protetoras; Ratos; Espécies Reativas de Oxigênio; Sirtuína 3/administração & dosagem; Superóxido Dismutase/genética; Transfecção

Palavras-chave

ageing; antioxidant capacity; cell transplantation; gene modification; human mesenchymal stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article