Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.

Perez Jimenez, Tania E; Mealey, Katrina L; Schnider, Darren; Grubb, Tamara L; Greene, Stephen A; Court, Michael H

Perez Jimenez, Tania E; Mealey, Katrina L; Schnider, Darren; Grubb, Tamara L; Greene, Stephen A; Court, Michael H.

Afiliação

Perez Jimenez TE; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
Mealey KL; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
Schnider D; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
Grubb TL; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
Greene SA; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.
Court MH; Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, Pharmacogenomics Laboratory, Washington State University College of Veterinary Medicine, Pullman, Washington.

J Vet Pharmacol Ther ; 41(6): 815-824, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30113702

Assuntos

Analgésicos Opioides/metabolismo; Hidrocarboneto de Aril Hidroxilases/metabolismo; Família 2 do Citocromo P450/metabolismo; Cães/metabolismo; Microssomos Hepáticos/metabolismo; Esteroide Hidroxilases/metabolismo; Tramadol/metabolismo; Animais; Hidrocarboneto de Aril Hidroxilases/antagonistas & inibidores; Hidrocarboneto de Aril Hidroxilases/genética; Gatos/metabolismo; Família 2 do Citocromo P450/antagonistas & inibidores; Família 2 do Citocromo P450/genética; Inibidores Enzimáticos/farmacologia; Feminino; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Masculino; Especificidade da Espécie; Esteroide Hidroxilases/antagonistas & inibidores; Esteroide Hidroxilases/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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