T lymphocytes as therapeutic arsenal for patients with hematological malignancies.
Curr Opin Oncol
; 30(6): 425-434, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30124521
ABSTRACT
PURPOSE OF REVIEW We present an overview of the clinically available immunotherapeutic platforms centered on T cell lymphocytes for the treatment of hematological malignancies with a special focus on the advances achieved since 2017. RECENT FINDINGS:
The most promising strategies of T cell therapies are based on the infusion of unmanipulated donor lymphocytes, antigen-specific T cells, ex-vivo genetically modified T cells or in-vivo manipulation of T cells using antibodies (bispecific and checkpoint inhibitors). To select the most appropriate option for a specific patient, is important to understand not only each platform-specific biological mechanisms, clinical activity and toxicities but also their intrinsic differences. In this extremely fast-growing field, to keep track of recent advances is a hard and challenging task for a hematologist. Therefore, we aimed to provide a global integrative review of T-cell-based immunotherapies, essential to ascertain their optimal place and timing in our daily clinical practice.SUMMARY:
We highlight recent advances and discuss future directions of T-cell-based immunotherapies entering the common clinical practice in hematology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article