Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.

Zhou, Li; Hossain, M Ibrahim; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Konno, Kohtaro; Kageyama, Shun; Komatsu, Masaaki; Watanabe, Masahiko; Sakimura, Kenji; Takebayashi, Hirohide

Zhou, Li; Hossain, M Ibrahim; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Konno, Kohtaro; Kageyama, Shun; Komatsu, Masaaki; Watanabe, Masahiko; Sakimura, Kenji; Takebayashi, Hirohide.

Afiliação

Zhou L; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Hossain MI; Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yamazaki M; Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Abe M; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Natsume R; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Konno K; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
Kageyama S; Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Komatsu M; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Watanabe M; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Sakimura K; Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Takebayashi H; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.

J Neurochem ; 147(4): 557-572, 2018 11.

Article em En | MEDLINE | ID: mdl-30225910

Assuntos

Proteínas de Ligação ao GTP/genética; Degeneração Neural/genética; Degeneração Neural/patologia; Células de Purkinje/patologia; D-Ala-D-Ala Carboxipeptidase Tipo Serina/genética; Alelos; Animais; Comportamento Animal; Carboxipeptidases; Ataxia Cerebelar/genética; Cerebelo/metabolismo; Cerebelo/patologia; Estresse do Retículo Endoplasmático/genética; Éxons/genética; Feminino; Deleção de Genes; Masculino; Camundongos; Camundongos Knockout; Mutação/genética; Degeneração Neural/psicologia; Fenótipo; Desempenho Psicomotor; Fator de Transcrição CHOP/genética; Fator de Transcrição CHOP/metabolismo; Tubulina (Proteína)/genética; Tubulina (Proteína)/metabolismo

Palavras-chave

Agtpbp1; CCP1; Nna1; Purkinje cell degeneration (pcd); conditional allele; knockout mice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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