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Subtype-specific inherited predisposition to pemphigus in the Chinese population.
Zhang, S Y; Zhou, X Y; Zhou, X L; Zhang, Y; Deng, Y; Liao, F; Yang, M; Xia, X Y; Zhou, Y H; Yin, D D; Ojaswi, P; Hou, Q Q; Wang, L; Zhang, D Y; Xia, D M; Deng, Y Q; Ding, L; Liu, H J; Yan, W; Li, M M; Ma, W T; Ma, J J; Yu, Q; Liu, B; Yang, L; Zhang, W; Shu, Y; Xu, H; Li, W.
Afiliação
  • Zhang SY; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Zhou XY; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Zhou XL; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Zhang Y; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Deng Y; Department of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Liao F; National Office for Maternal and Child Health Surveillance of China, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yang M; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Xia XY; Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Zhou YH; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Yin DD; Department of Laboratory Medicine, Research Center of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ojaswi P; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Hou QQ; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Wang L; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Zhang DY; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Xia DM; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Deng YQ; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Ding L; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Liu HJ; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Yan W; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Li MM; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Ma WT; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Ma JJ; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Yu Q; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Liu B; Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan, China, 610041.
  • Yang L; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
  • Zhang W; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
  • Shu Y; Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, China.
  • Xu H; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
  • Li W; Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China, 610041.
Br J Dermatol ; 180(4): 828-835, 2019 04.
Article em En | MEDLINE | ID: mdl-30230522
ABSTRACT

BACKGROUND:

Pemphigus is a group of rare life-threatening mucocutaneous autoimmune diseases, presenting mainly as two subtypes pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Inherited predispositions to pemphigus have long been speculated but they remain poorly understood.

OBJECTIVES:

To identify common and specific nongenetic and genetic factors associated with pemphigus and its subtypes in the Chinese population.

METHODS:

A genome-wide association study (GWAS) was performed in 496 unrelated patients with pemphigus (including 365 with PV and 104 with PF) and 1105 controls without pemphigus.

RESULTS:

A sex preference was observed only in PV (57·5% female) and not in PF (47·1% female). For male patients only, the mean age at diagnosis was significantly lower for PV than for PF (P < 0·001). The strongest associated single-nucleotide polymorphisms are in the human leucocyte antigen (HLA) region rs70993900 (PV; P = 1·5 × 10-45 ) and rs9469220 (PF; P = 1·1 × 10-8 ). HLA-DQB1*0503 ranks at the top (P = 4·7 × 10-40 ; odds ratio 12·4) in both subtypes, with significantly different risk allele frequency (RAFPV = 34·2% vs. RAFPF = 18·8% vs. RAFcontrol = 4·4%), whereas HLA-DRB1*1401 and HLA-DRB1*0406 are PV specific. HLA-DQB1*0303 and HLA-DQB1*0302 show significant subtype specificity in opposite directions. All of these associations were validated in the replication series with 147 cases of pemphigus and 604 controls. Multiple novel non-HLA susceptibility loci were also identified in the GWAS.

CONCLUSIONS:

This study represents the largest GWAS on pemphigus in the Chinese population published to date, and has allowed us to identify HLA haplotypes significantly shared between or specific to the two main subtypes of pemphigus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article