Microarray analysis of altered long non-coding RNA expression profile in liver cancer cells treated by ginsenoside Rh2.
J Asian Nat Prod Res
; 21(8): 742-753, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-30394104
ABSTRACT
Microarray expression profiles of lncRNAs and mRNAs were investigated in HepG2 cells treated with 20 µg/ml ginsenoside Rh2 as well as in ginsenoside Rh2-untreated cells. Microarray analysis showed 618 upregulated lncRNAs and 161 downregulated lncRNAs in HepG2 cells treated with ginsenoside Rh2 compared with the control group. Moreover, three differentially expressed lncRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). This may be beneficial to patients as an anti-cancer treatment and potentially provide novel targets for HCC (hepatocellular carcinoma) therapy.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article