Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer.

Suehiro, Yuki; Takemoto, Yoshihiro; Nishimoto, Arata; Ueno, Koji; Shirasawa, Bungo; Tanaka, Toshiki; Kugimiya, Naruji; Suga, Atsushi; Harada, Eijiro; Hamano, Kimikazu

Suehiro, Yuki; Takemoto, Yoshihiro; Nishimoto, Arata; Ueno, Koji; Shirasawa, Bungo; Tanaka, Toshiki; Kugimiya, Naruji; Suga, Atsushi; Harada, Eijiro; Hamano, Kimikazu.

Afiliação

Suehiro Y; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Takemoto Y; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan ytake@yamaguchi-u.ac.jp anishimo@yamaguchi-u.ac.jp.
Nishimoto A; Department of Medical Education, Yamaguchi University Graduate School of Medicine, Ube, Japan ytake@yamaguchi-u.ac.jp anishimo@yamaguchi-u.ac.jp.
Ueno K; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Shirasawa B; Department of Medical Education, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Tanaka T; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Kugimiya N; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Suga A; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Harada E; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Hamano K; Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Anticancer Res ; 38(11): 6225-6230, 2018 Nov.

Article em En | MEDLINE | ID: mdl-30396941

Assuntos

Benzodiazepinonas/farmacologia; Quinase 1 do Ponto de Checagem/metabolismo; Neoplasias do Colo/metabolismo; Fluoruracila/farmacologia; Poli(ADP-Ribose) Polimerase-1/metabolismo; Pirimidinas/farmacologia; Pontos de Checagem do Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Neoplasias do Colo/tratamento farmacológico; Sinergismo Farmacológico; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Fosforilação/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

5-fluorouracil; Colorectal cancer; LRRK2-IN-1; cell-cycle arrest; checkpoint kinase 1 phosphorylation; cytotoxicity; doublecortin-like kinase 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article