ß-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3ß.

Lee, Sang-Kyu; Jeong, Woo-Jeong; Cho, Yong-Hee; Cha, Pu-Hyeon; Yoon, Jeong-Su; Ro, Eun Ji; Choi, Sooho; Oh, Jeong-Min; Heo, Yunseok; Kim, Hyuntae; Min, Do Sik; Han, Gyoonhee; Lee, Weontae; Choi, Kang-Yell

Lee, Sang-Kyu; Jeong, Woo-Jeong; Cho, Yong-Hee; Cha, Pu-Hyeon; Yoon, Jeong-Su; Ro, Eun Ji; Choi, Sooho; Oh, Jeong-Min; Heo, Yunseok; Kim, Hyuntae; Min, Do Sik; Han, Gyoonhee; Lee, Weontae; Choi, Kang-Yell.

Afiliação

Lee SK; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Jeong WJ; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Cho YH; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Cha PH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Yoon JS; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Ro EJ; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Choi S; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Oh JM; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Heo Y; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Kim H; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Min DS; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Han G; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Lee W; Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Choi KY; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.

EMBO Rep ; 19(12)2018 12.

Article em En | MEDLINE | ID: mdl-30413483

Assuntos

Glicogênio Sintase Quinase 3 beta/metabolismo; Proteólise; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; beta Catenina/metabolismo; Animais; Linhagem Celular Tumoral; Transformação Celular Neoplásica; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Células HEK293; Humanos; Camundongos Nus; Modelos Biológicos; Modelos Moleculares; Mutação/genética; Peptídeos/metabolismo; Fosforilação; Ligação Proteica; Domínios Proteicos; Via de Sinalização Wnt; Ensaios Antitumorais Modelo de Xenoenxerto; beta Catenina/química; beta Catenina/genética

Palavras-chave

GSK3ß phosphorylation of RAS; colorectal cancer; regulation of RAS stability; αInterface region of RAS; ßCateninRAS interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article