Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.

Woo, Seong Ji; Noh, Hae Sook; Lee, Na Young; Cheon, Yun-Hong; Yi, Sang Mi; Jeon, Hyun Min; Bae, Eun Ju; Lee, Sang-Il; Park, Byung-Hyun

Woo, Seong Ji; Noh, Hae Sook; Lee, Na Young; Cheon, Yun-Hong; Yi, Sang Mi; Jeon, Hyun Min; Bae, Eun Ju; Lee, Sang-Il; Park, Byung-Hyun.

Afiliação

Woo SJ; Department of Biochemistry and Molecular Biology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.
Noh HS; Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 52828, Republic of Korea.
Lee NY; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.
Cheon YH; Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 52828, Republic of Korea.
Yi SM; Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 52828, Republic of Korea.
Jeon HM; Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 52828, Republic of Korea.
Bae EJ; College of Pharmacy, Woosuk University, Wanju, Jeonbuk 55338, Republic of Korea.
Lee SI; Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 52828, Republic of Korea. Electronic address: goldgu@gnu.ac.kr.
Park BH; Department of Biochemistry and Molecular Biology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea. Electronic address: bhpark@jbnu.ac.kr.

EBioMedicine ; 38: 228-237, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30429089

Assuntos

Artrite Reumatoide/etiologia; Artrite Reumatoide/metabolismo; Ativação de Macrófagos/genética; Macrófagos/metabolismo; Células Mieloides/metabolismo; Sirtuínas/deficiência; Animais; Artrite Experimental; Artrite Reumatoide/diagnóstico por imagem; Artrite Reumatoide/patologia; Biomarcadores; Movimento Celular/imunologia; Sobrevivência Celular; Quimiotaxia de Leucócito/genética; Quimiotaxia de Leucócito/imunologia; Modelos Animais de Doenças; Expressão Gênica; Humanos; Ativação de Macrófagos/imunologia; Macrófagos/imunologia; Camundongos; Modelos Biológicos; Células Mieloides/imunologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Transporte Proteico; Proteólise; Índice de Gravidade de Doença; Sirtuínas/genética; Sirtuínas/metabolismo; Membrana Sinovial/imunologia; Membrana Sinovial/patologia

Palavras-chave

FoxO1; Inflammation; Macrophage; RA; Sirt6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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