Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos, N; Durrant, T N; Chessa, T; Suire, S M; Oxley, D; Kulkarni, S; Downward, J; Perisic, O; Williams, R L; Stephens, L; Hawkins, P T

Tsolakos, N; Durrant, T N; Chessa, T; Suire, S M; Oxley, D; Kulkarni, S; Downward, J; Perisic, O; Williams, R L; Stephens, L; Hawkins, P T.

Afiliação

Tsolakos N; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom.
Durrant TN; Department of Chemistry, University of Oxford, OX1 3QZ Oxford, United Kingdom.
Chessa T; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom.
Suire SM; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom.
Oxley D; The Mass Spec Facility, The Babraham Institute, CB22 3AT Cambridge, United Kingdom.
Kulkarni S; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom.
Downward J; The Oncogene Biology Lab, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Perisic O; Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, CB2 0QH Cambridge, United Kingdom.
Williams RL; Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, CB2 0QH Cambridge, United Kingdom.
Stephens L; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom; len.stephens@babraham.ac.uk phillip.hawkins@babraham.ac.uk.
Hawkins PT; The Signaling Department, The Babraham Institute, CB22 3AT Cambridge, United Kingdom; len.stephens@babraham.ac.uk phillip.hawkins@babraham.ac.uk.

Proc Natl Acad Sci U S A ; 115(48): 12176-12181, 2018 11 27.

Article em En | MEDLINE | ID: mdl-30442661

Assuntos

Classe Ia de Fosfatidilinositol 3-Quinase/metabolismo; Isoformas de Proteínas/metabolismo; Receptores do Fator de Crescimento Derivado de Plaquetas/metabolismo; Animais; Classe Ia de Fosfatidilinositol 3-Quinase/genética; Dimerização; Fibroblastos/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fosforilação; Ligação Proteica; Isoformas de Proteínas/genética; Receptor beta de Fator de Crescimento Derivado de Plaquetas/genética; Receptor beta de Fator de Crescimento Derivado de Plaquetas/metabolismo; Receptores do Fator de Crescimento Derivado de Plaquetas/genética; Transdução de Sinais

Palavras-chave

Avi-tag; PI3K; isoform-selective

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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