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Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.
Guillon, Christophe D; Jan, Yi-Hua; Foster, Natalie; Ressner, Joel; Heck, Diane E; Laskin, Jeffrey D; Heindel, Ned D.
Afiliação
  • Guillon CD; Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA. Electronic address: chg3@lehigh.edu.
  • Jan YH; Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
  • Foster N; Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
  • Ressner J; Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
  • Heck DE; Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, USA.
  • Laskin JD; Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
  • Heindel ND; Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
Bioorg Med Chem Lett ; 29(4): 619-622, 2019 02 15.
Article em En | MEDLINE | ID: mdl-30638875
ABSTRACT
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article