SMAD family member 3 (SMAD3) and SMAD4 repress HIF2&#945;-dependent iron-regulatory genes.

Ma, Xiaoya; Das, Nupur K; Castillo, Cristina; Gourani, Ayla; Perekatt, Ansu O; Verzi, Michael P; Shah, Yatrik M

SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.

Ma, Xiaoya; Das, Nupur K; Castillo, Cristina; Gourani, Ayla; Perekatt, Ansu O; Verzi, Michael P; Shah, Yatrik M.

Afiliação

Ma X; From the Departments of Molecular & Integrative Physiology and.
Das NK; From the Departments of Molecular & Integrative Physiology and.
Castillo C; From the Departments of Molecular & Integrative Physiology and.
Gourani A; From the Departments of Molecular & Integrative Physiology and.
Perekatt AO; the Department of Genetics, Human Genetics Institute, and Rutgers Cancer Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854.
Verzi MP; the Department of Genetics, Human Genetics Institute, and Rutgers Cancer Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854.
Shah YM; From the Departments of Molecular & Integrative Physiology and shahy@umich.edu.

J Biol Chem ; 294(11): 3974-3986, 2019 03 15.

Article em En | MEDLINE | ID: mdl-30659096

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Proteínas Reguladoras de Ferro/metabolismo; Proteína Smad3/metabolismo; Proteína Smad4/metabolismo; Animais; Células Cultivadas; Humanos; Proteínas Reguladoras de Ferro/genética; Camundongos; Camundongos Knockout; Proteína Smad3/deficiência; Proteína Smad4/deficiência

Palavras-chave

DMT1; HIF; Iron; SMAD; SMAD transcription factor; gene expression; hypoxia; iron; iron metabolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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