Amyloid-ß Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity.

Honcharenko, Dmytro; Juneja, Alok; Roshan, Firoz; Maity, Jyotirmoy; Galán-Acosta, Lorena; Biverstål, Henrik; Hjorth, Erik; Johansson, Jan; Fisahn, André; Nilsson, Lennart; Strömberg, Roger

Honcharenko, Dmytro; Juneja, Alok; Roshan, Firoz; Maity, Jyotirmoy; Galán-Acosta, Lorena; Biverstål, Henrik; Hjorth, Erik; Johansson, Jan; Fisahn, André; Nilsson, Lennart; Strömberg, Roger.

Afiliação

Honcharenko D; Department of Biosciences and Nutrition , Karolinska Institutet , 14183 Huddinge , Sweden.
Juneja A; Department of Biosciences and Nutrition , Karolinska Institutet , 14183 Huddinge , Sweden.
Roshan F; Neuronal Oscillations Laboratory, Neurogeriatrics Division, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 17164 Solna , Sweden.
Maity J; Department of Biosciences and Nutrition , Karolinska Institutet , 14183 Huddinge , Sweden.
Galán-Acosta L; Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 14183 Stockholm , Sweden.
Biverstål H; Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 14183 Stockholm , Sweden.
Hjorth E; Department of Physical Organic Chemistry , Latvian Institute of Organic Synthesis , Riga LV-1006 , Latvia.
Johansson J; Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 14183 Stockholm , Sweden.
Fisahn A; Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 14183 Stockholm , Sweden.
Nilsson L; Neuronal Oscillations Laboratory, Neurogeriatrics Division, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society , Karolinska Institutet , 17164 Solna , Sweden.
Strömberg R; Department of Biosciences and Nutrition , Karolinska Institutet , 14183 Huddinge , Sweden.

ACS Chem Neurosci ; 10(3): 1462-1477, 2019 03 20.

Article em En | MEDLINE | ID: mdl-30673220

Assuntos

Peptídeos beta-Amiloides/toxicidade; Sistemas de Liberação de Medicamentos/métodos; Simulação de Dinâmica Molecular; Fragmentos de Peptídeos/administração & dosagem; Peptidomiméticos/administração & dosagem; Peptídeos beta-Amiloides/antagonistas & inibidores; Peptídeos beta-Amiloides/metabolismo; Animais; Linhagem Celular Tumoral; Feminino; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Humanos; Ligantes; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Técnicas de Cultura de Órgãos; Fragmentos de Peptídeos/antagonistas & inibidores; Fragmentos de Peptídeos/metabolismo; Fragmentos de Peptídeos/toxicidade; Peptidomiméticos/metabolismo

Palavras-chave

Alzheimer's disease; amyloid-ß peptide; gamma oscillations; molecular dynamics; synthetic ligands; α-helical conformation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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