Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-ß and JNK Signaling Pathways in Esophageal Cancer.

Blum, Andrew E; Venkitachalam, Srividya; Ravillah, Durgadevi; Chelluboyina, Aruna K; Kieber-Emmons, Ann Marie; Ravi, Lakshmeswari; Kresak, Adam; Chandar, Apoorva K; Markowitz, Sanford D; Canto, Marcia I; Wang, Jean S; Shaheen, Nicholas J; Guo, Yan; Shyr, Yu; Willis, Joseph E; Chak, Amitabh; Varadan, Vinay; Guda, Kishore

Blum, Andrew E; Venkitachalam, Srividya; Ravillah, Durgadevi; Chelluboyina, Aruna K; Kieber-Emmons, Ann Marie; Ravi, Lakshmeswari; Kresak, Adam; Chandar, Apoorva K; Markowitz, Sanford D; Canto, Marcia I; Wang, Jean S; Shaheen, Nicholas J; Guo, Yan; Shyr, Yu; Willis, Joseph E; Chak, Amitabh; Varadan, Vinay; Guda, Kishore.

Afiliação

Blum AE; Division of Gastroenterology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Division of Gastr
Venkitachalam S; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Ravillah D; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Chelluboyina AK; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Kieber-Emmons AM; Division of Gastroenterology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Ravi L; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Kresak A; Department of Pathology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Chandar AK; Division of Gastroenterology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Markowitz SD; Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Canto MI; Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
Wang JS; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Shaheen NJ; Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina.
Guo Y; Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, Tennessee.
Shyr Y; Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, Tennessee.
Willis JE; Department of Pathology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Chak A; Division of Gastroenterology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Varadan V; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Guda K; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: kkg5@case.edu.

Gastroenterology ; 156(6): 1761-1774, 2019 05.

Article em En | MEDLINE | ID: mdl-30768984

Assuntos

Adenocarcinoma/genética; Adenocarcinoma/metabolismo; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Sistema de Sinalização das MAP Quinases/genética; RNA Neoplásico/análise; Fator de Crescimento Transformador beta/metabolismo; Animais; Esôfago de Barrett/genética; Esôfago de Barrett/metabolismo; Esôfago de Barrett/patologia; Benzamidas/farmacologia; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Dioxóis/farmacologia; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Masculino; Camundongos; Transplante de Neoplasias; Análise de Sequência com Séries de Oligonucleotídeos; Testes Farmacogenômicos; Proteínas Proto-Oncogênicas c-jun/metabolismo; Pirazóis/farmacologia; Quinolinas/farmacologia; Receptores de Fatores de Crescimento Transformadores beta/antagonistas & inibidores; Proteínas Smad/genética; Proteínas Smad/metabolismo; Biologia de Sistemas; Transcriptoma; Fator de Crescimento Transformador beta/antagonistas & inibidores; Fator de Crescimento Transformador beta/genética; Ensaio Tumoral de Célula-Tronco

Palavras-chave

InFlo; LY2157299; PARADIGM; SP600125

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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