Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKC&#945;/eNOS and PI3K/Akt/eNOS pathways.

Zhang, Song; Guo, Shun; Gao, Xiao-Bo; Liu, An; Jiang, Wei; Chen, Xi; Yang, Peng; Liu, Lin-Na; Shi, Lei; Zhang, Yan

Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways.

Zhang, Song; Guo, Shun; Gao, Xiao-Bo; Liu, An; Jiang, Wei; Chen, Xi; Yang, Peng; Liu, Lin-Na; Shi, Lei; Zhang, Yan.

Afiliação

Zhang S; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Guo S; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Gao XB; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Liu A; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Jiang W; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Chen X; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Yang P; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Liu LN; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Shi L; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.
Zhang Y; Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.

J Cell Mol Med ; 23(4): 2731-2743, 2019 04.

Article em En | MEDLINE | ID: mdl-30770623

Assuntos

Alcaloides/farmacologia; Dieta Hiperlipídica/efeitos adversos; Endotélio Vascular/efeitos dos fármacos; Regulação da Expressão Gênica/efeitos dos fármacos; Lipoproteínas LDL/toxicidade; Quinolizinas/farmacologia; Lesões do Sistema Vascular/prevenção & controle; Animais; Endotélio Vascular/metabolismo; Endotélio Vascular/patologia; Células Endoteliais da Veia Umbilical Humana; Humanos; Técnicas In Vitro; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/genética; Óxido Nítrico Sintase Tipo III/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteína Quinase C-alfa/genética; Proteína Quinase C-alfa/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Lesões do Sistema Vascular/etiologia; Lesões do Sistema Vascular/metabolismo; Lesões do Sistema Vascular/patologia; Matrinas

Palavras-chave

PI3K/Akt; PKCα; matrine; obesity; vascular endothelial injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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